Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease

WHO states that the number of people suffering from dementia worldwide is likely to triple by 2050. According to statistics, the number of dementia cases increase to 25-50% as the age rises over 85. Khan S. et al looked into the pathophysiology, current advances and future approaches of the Alzheimer's disease treatment and diagnosis. Newer strategies in early detection include a development of an affordable and feasible blood test to be performed in any clinical setup. Although such prognostic and diagnostic biomarkers as amyloid-β and tau protein are available for Alzheimer’s disease, only few patients are tested due to it's high cost and restricted access. Difficulties in the treatment approach are explained by the early pathologic changes, that may begin decade before the person shows the symptoms. As of today, no drug is available that has a curative effect. Only the treatment relieving the symptoms is currently approved. One of the latest technologies is theranostics, which combines therapeutics and diagnostics. Detailed explanation is by the link.