Osteoarthritis pathogenesis and new approaches

Osteoarthritis (OA) is the most common form of arthritis with a 113.25 percent increase in prevalent cases globally from 1990 to 2019. An article published in Bone Research Journal this September (2022) focuses on the epigenetic regulation of OA, with a particular insight on DNA, that can become a new molecular target for OA treatment in the clinic. Authors also present several innovative techniques for management of OA-associated pain, such as CRISPR- a system, targeting nucleic acids, to manipulate genetic information. Genome editing has benefits of flexibility, programmability, and high efficiency and could be successfully used to treat OA. The application of described techniques is accelerating the understanding of OA pathogenesis and is aimed to develop more specific and effective therapeutic interventions.