Knee Osteoarthritis: Novel Non-Operative Therapeutic Considerations

The prevalence of knee osteoarthritis (OA) among adults 60+ years old is nearly 10% in men and 13% in women. Authors from Croatia and US provide a detailed pathogenesis review of the changes in articular cartilage, subchondral bone, synovium, ligaments and tendons with progression of this pathology. Over the years, a lot of research effort has been put into discovering the best treatment strategy. Such remedies as Platelet-Rich Plasma, Bone Marrow Mesenchymal Stem Cells, Autologous Adipose Tissue have already been widely used with mixed results. A one-treatment-fits-all approach may have poor outcomes due to multiple etiology of OA. As such, treatment options that target specific mechanisms is the future. Gene therapy, monoclonal antibodies and phenotyping are among the most perspective developments. More by the link!