According to WHO reports, headache on 15 or more days every month affects 1.7–4% of the world’s adult population. But is there a golden standard for the treatment plan? American Headache Society has the answer! The FDA approved the combination of 3 drugs- acetylsalicylic acid (250 mg), acetaminophen (250 mg), and caffeine (65 mg) as safe and effective in treating acute headaches, especially migraine. Each component has a different mechanism of action, so accumulation of these effects provides a notable result. It has been reported that adding 100 mg caffeine to a commonly used analgesics provides a significant increase in pain relief. Acetaminophen is the drug of choice in patients who cannot use non-steroidal anti-inflammatory drugs (NSAIDs) and also safer to use than opioids for chronic pain. Aspirin is a known first-line therapy for moderate to severe primary headaches, its intravenous administration for inpatient management is considered safe and effective. Get the details by the link.