Hemoperfusion: technical aspects
Article published in Critical Care Journal by Ronco et al provides a narrative literature review focusing on the technology, characteristics, and principles of hemoperfusion. For years, bioincompatibility was the main safe issue for this procedure. Recent technology, however, helps to remove unwanted plasma solutes by direct adsorption. Blood purification can be achieved by various mass separation process options: diffusion, convection, solute adsorption. Sorbents have been studied well over the years and as of today are generally produced in granules, beads, or fibers. Some small toxic solutes can be removed by dialysis or by adsorption to sorbents beads. However, large solutes can only be removed by plasma exchange. This technique allow to remove molecules that are toxic in sepsis or severe liver failure. All the benefits and disadvantages of these methods by the link!