Fibrin glue for skin grafts

The Australian study aimed to evaluate existing literature concerning the efficacy of fibrin glue in enhancing the survival rate of skin grafts. Comprised of thrombin, factor XIII, calcium, and fibrinogen, fibrin glue was initially designed as a hemostatic agent. When applied to a wound, it corresponds to the final stages of the clotting process, converting into fibrin. Exploration into the use of fibrin glue in skin grafts for burn victims involved comparisons with staples or sutures for wound closure. Its ability to bind the entire graft surface to the wound area potentially minimizes the formation of hematoma or seroma immediately post-operation. Research has also highlighted reduced reliance on dressings for ensuring graft adherence, improved hemostasis, and diminished scar tissue contraction across various skin graft applications. Despite extensive investigation, current published literature fails to definitively establish fibrin glue as superior to its comparators. However, a handful of papers have demonstrated decreased pain during dressing changes among patients treated with fibrin glue.