Alzheimer's disease: new treatment strategies

Alzheimer's disease (AD) is considered the most common type of neurodegenerative disease, occurring in 60-80% of all cases. The pathology of AD is a consequence of both structural and functional damage to the central nervous system. Authors from France review current treatments, focusing on prevention strategies. Common medical treatments for AD are symptom-based rather than treatment-based to limit the progression of cognitive, behavioral, and psychological symptoms of dementia. Four drugs - donepezil, memantine, galantamine, rivastigmine - are allowed on the market. Of greatest interest in recent research is prevention through non-pharmacological treatments. Because lipids play an important role in brain structure and function, dietary intervention is an important strategy to reduce age-related cognitive impairment. However, the most promising technology is soft nanoparticles such as nanoliposomes and exosomes, an innovative approach to reduce the risk of AD and address brain bioavailability issues. More details in the original article.