Aging of hair follicle stem cells

A research study from Korea presents an overview of how age-related intrinsic and extrinsic factors contribute to hair loss and aging. The hair follicle undergoes cycles of regeneration and regression throughout a lifetime. Various types of skin-associated stem cells, including those linked to hair, have been identified. Stem cells possess the unique ability to self-renew and generate specialized cell types. However, aging impacts adult stem cells residing in hair follicles, leading to a thinning of hair, reduced hair production, and the onset of graying and hair loss.
FDA-approved synthetic drugs like minoxidil and finasteride are among several treatments available. Transplantation therapy serves as an option for recovering from general alopecia. Strategies such as platelet-rich plasma therapy and mitochondrial transplantation show promise in activating stem cells for hair loss treatment. Another approach, photobiomodulation therapy, holds FDA approval for alopecia treatment and has the potential to reduce age-related follicle atrophy. This collective understanding underscores diverse treatment avenues for addressing hair loss and aging-related concerns.